منابع مشابه
The pulmonary extracellular lining.
The extracellular lining of the lungs is reviewed. The pulmonary extracellular lining is a complex mixture of phospholipids, proteins and carbohydrates which is absolutely essential for the maintenance of normal pulmonary functions such as gas exchange. Without the lining the lungs would collapse. Alterations in the pulmonary extracellular lining may underlie some disease conditions induced by ...
متن کاملCharacterization of the extracellular bactericidal factors of rat alveolar lining material.
The surfactant fraction (55,000-g pellet) of leukocyte-free rat bronchoalveolar lavage fluid contains factors that rapidly kill and lyse pneumococci. These factors were purified and identified biochemically by using a quantitative bactericidal test to monitor fractionation procedures. 91% of the antipneumococcal activity of rat surfactant was recovered in chloroform after extraction of rat surf...
متن کاملNO2-induced generation of extracellular reactive oxygen is mediated by epithelial lining layer antioxidants.
Nitrogen dioxide (NO2) is an environmental oxidant that causes acute lung injury. Absorption of this aqueous insoluble gas into the epithelial lining fluid (ELF) that covers air space surfaces is, in part, governed by reactions with ELF constituents. Consequently, NO2absorption is coupled to its chemical elimination and the formation of ELF-derived products. To investigate mechanisms of acute e...
متن کاملModeling In Vivo Interactions of Engineered Nanoparticles in the Pulmonary Alveolar Lining Fluid
Increasing use of engineered nanomaterials (ENMs) in consumer products may result in widespread human inhalation exposures. Due to their high surface area per unit mass, inhaled ENMs interact with multiple components of the pulmonary system, and these interactions affect their ultimate fate in the body. Modeling of ENM transport and clearance in vivo has traditionally treated tissues as well-mi...
متن کاملExtracellular Vesicles in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is characterized by the progression of irreversible airflow limitation and is a leading cause of morbidity and mortality worldwide. Although several crucial mechanisms of COPD pathogenesis have been studied, the precise mechanism remains unknown. Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, are released from ...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1984
ISSN: 0091-6765
DOI: 10.2307/3429705